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Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells

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Title Effect of near field ultrasound on carboplatin treatment of ovarian carcinoma cells
 
Creator Bernard, Vladan
Mornstein, Vojtěch
Bourek, Aleš
 
Subject Carboplatin
Ovarian carcinoma cells
Sonodynamic action
Ultrasound
Viability
 
Description 284-288
It has long been shown that therapeutic ultrasound has the
potential to affect cells surfaces and membranes. In this study, the effects of
ultrasound in near field mode, the anti-cancer drug carboplatin and their
combined application were studied on human carcinoma cells A2780. Four modes of
treatment were used: exposure to ultrasonic field, application of carboplatin,
exposure to ultrasound followed by carboplatin and carboplatin treatment
followed by exposure to near field ultrasound. The value of viability was
measured by standard MTT test. The value of ultrasound intensity was set 1 W·cm-2 and
1 MHz frequency was used. The real value of acoustic pressure during in vitro experiments was assessed by
hydrophone. The results showed that a combined effect of ultrasound and
carboplatin influenced the viability of human carcinoma cells
A2780 more than
the application of ultrasound or carboplatin alone. It could be assumed
that exposure of cells to ultrasonic field had an immediate effect on the
structure of cell surface and consequently on the entry of carboplatin into the
cell. The results of our experiments demonstrated possibility of using
therapeutic ultrasound in potentiating the cytostatic
treatment of human carcinoma cells.


 
Date 2013-09-01T13:10:30Z
2013-09-01T13:10:30Z
2013-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/20876
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(4) [August 2013]