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Protective effect of some amino acids synthesized derivatives and their chelates on <i style="mso-bidi-font-style: normal">Escherichia coli</i> under X-ray irradiation

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Title Protective effect of some amino acids synthesized derivatives and their chelates on Escherichia coli under X-ray irradiation
 
Creator Kirakosyan, G
Torgomyan, H
Malakyan, M
Bajinyan, S
Trchounian, A
 
Subject X-ray irradiation
Radio-protective compounds
Bacterial growth and survival
ATPase activity
Escherichia coli
 
Description 289-295
The protective effects of novel synthesized derivatives of some amino acids — nicotinyl-L-tyrosinate
and
nicotinyl-L-tryptophanate schiff bases and their Cu(II) and Mn(II) chelates on growth, survival and
membrane-associated ATPase activity of E. coli under X-ray irradiation were
investigated. The specific
growth rate and survival of E. coli were
decreased at 10, 20 and 30 Gy doses. However, as 30 Gy
was found to be the most effective irradiation dose, it was chosen for studying
the radio-protective properties of different compounds. These compounds could increase the
bacterial cell protection against X-ray irradiation in concentration-dependent manner.
They had a role in stimulation of synthesis or regulation of activity of
metal-dependent enzymes, required for reversing the X-ray irradiation damage. The study
may prove useful for further estimation of the effectiveness of different
compounds as radio-protectors on bacteria and other cells,
especially mammalian cells under X-ray irradiation.
 
Date 2013-09-01T13:12:20Z
2013-09-01T13:12:20Z
2013-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/20877
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(4) [August 2013]