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<span style="font-size:15.0pt;mso-bidi-font-size:16.0pt; mso-bidi-font-weight:bold;font-style:normal" lang="EN-US">Wound healing potential of flowers extracts of <span style="font-size:15.0pt;mso-bidi-font-size: 16.0pt;mso-bidi-font-weight:bold" lang="EN-US">Woodfordia fruticosa<span style="font-size:15.0pt;mso-bidi-font-size:16.0pt;mso-bidi-font-weight:bold; font-style:normal" lang="EN-US"> Kurz. </span></span></span>

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Title Wound healing potential of flowers extracts of Woodfordia fruticosa Kurz.
 
Creator Verma, Neeraj
Amresh, G
Sahu, P K
Mishra, Neelam
Rao, Ch V
Singh, Anil Pratap
 
Subject Anti-inflammatory cytokines
Antimicrobial
Dead space
Excision
Incision
Pro-inflammatory cytokines
Woodfordia fruticosa
Wound healing
 
Description 296-304
Wound healing or repair is the body’s natural
process of regenerating dermal and epidermal tissue. Woodfordia fruticosa Kurz (Family: Lythraceae) is used traditionally in wound healing by the
tribals of Chhattisgarh district. However, there is a paucity of scientific data
in support. In this study, we evaluated
antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous
extracts against a diverse range of gram +ve and gram -ve bacteria along with
pathogenic fungi. The wound healing activity of ethanolic
extract was also evaluated at dose levels of 250 and 500 mg/kg body wt in rats by excision, incision and dead space wound healing models along
with histopathology of wound area of skin. The ethanolic extract showed potent
wound healing activity, as evident from the increase in the wound contraction
and breaking strength in dose-dependent manner. Treatment with ethanolic
extract (250 and 500 mg/kg body wt) showed significant dose-dependently
decrease in epithelization period and scar area.
Hydroxyproline, hexuronic acid and hexosamine contents, the important
constituents of extracellular matrix of healing were
also correlated with the observed healing pattern. During early wound healing
phase, pro-inflammatory cytokines TNF-α, IL-6 and anti-inflammatory cytokine
IL-10 levels were found to be upregulated by the ethanolic extract treatment. The ethanolic
extract exhibited a strong and broad spectrum antimicrobial activity, as
compared to other extracts. It showed very low Minimum
inhibitory concentration (MIC) values and inhibited the growth of E.
coli, Staphylococcus aureus and Candida albicans in concentration of 2.5
µg/disc. Thus, the results of the present study
demonstrated the strong wound healing potential and antimicrobial activities of W.
fruticosa, flowers, supporting the
folklore use of the plant by the tribal people of Chhattisgarh district.
 
Date 2013-09-01T13:13:57Z
2013-09-01T13:13:57Z
2013-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/20878
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(4) [August 2013]