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Protease Inhibitors in Potential Drug Development for Leishmaniasis

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Title Protease Inhibitors in Potential Drug Development for Leishmaniasis
 
Creator Das, Partha
Alam, Md Nur
Paik, Dibyendu
Karmakar, Kanchan
De, Tripti
Chakraborti, Tapati
 
Subject Leishmania
Leishmaniasis
Proteases
Biochemical pathways
Drug targets
Inhibitors
Chemotherapy
 
Description 363-376
Leishmaniasis is a deadly protozoan
parasitic disease affecting millions of people worldwide. The treatment
strategy of Leishmania infection
depends exclusively on chemotherapy till date. But the treatment of the disease
is greatly hampered due to high cost, toxicity of the available drugs and more
importantly emergence of drug resistance. Hence the
potential new drugs are highly needed to
combat this disease. The first and foremost step of the drug discovery process
is to search and select the putative target in a specific biological pathway in
the parasite that should be either unambiguously absent in the host or
considerably different from the host homolog. Importantly, Leishmania genome sequences enrich our knowledge about Leishmania and simultaneously reinforce us to identify the ideal drug
targets that distinctly exist in the parasite as well as to develop the
effective drugs for leishmaniasis. Though the leishmanial
research has significantly progressed during the past
two decades, the identification of suitable
drug targets or development of effective drugs to combat leishmaniasis is far
from satisfactory. Enzymatic systems of Leishmania
metabolic and biochemical pathways are essential for their survival and
infection. Concurrently, it is noteworthy that Leishmania proteases, especially the cysteine proteases,
metalloproteases and serine proteases have been extensively investigated and
found to be indispensable for the survival of the parasites and disease
pathogenesis. Herein, we have discussed the
importance of few enzymes, particularly the Leishmania
proteases and their inhibitors as promising candidates for potential
development of anti-leishmanial drugs.
 
Date 2013-10-26T10:06:43Z
2013-10-26T10:06:43Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22654
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]