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Inflammation and MMPs in Alcohol-induced Liver Diseases and Protective Action of Antioxidants

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Title Inflammation and MMPs in Alcohol-induced Liver Diseases and Protective Action of Antioxidants
 
Creator Banerjee, Pamela
Jana, Sayantan
Chakraborty, Somsuta
Swarnakar, Snehasikta
 
Subject Alcoholic liver diseases
Antioxidants
Matrix metalloproteinase
Tissue inhibitor of MMPs
 
Description 377-386
The consumption of alcohol causes several
liver-associated diseases all over the world. Alcoholic liver diseases (ALD)
include hepatic inflammation, fatty liver, hepatitis, liver cirrhosis and
fibrosis and finally hepatocellular carcinoma. Although the cellular, metabolic
and biochemical mechanisms for these diseases are quite explicable, the roles
of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are
still under investigation. The present review describes the roles and
regulation of MMPs and TIMPs in different ALDs along with the involvement of
other pathways. This review also summarizes the present knowledge on clinical
and experimental trials with different antioxidants that help against alcohol
associated liver diseases.
 
Date 2013-10-26T10:07:44Z
2013-10-26T10:07:44Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22655
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]