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Aluminum and ethanol induce alterations in superoxide and peroxide handling capacity (SPHC) in frontal and temporal cortex

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Title Aluminum and ethanol induce alterations in superoxide and peroxide handling capacity (SPHC) in frontal and temporal cortex
 
Creator Nayak, Prasunpriya
Sharma, S B
Chowdary, N V S
 
Subject Aluminum
Brain
Catalase
Glutathione
Superoxide dismutase
Spontaneous motor activity
Rota-Rod performance.
 
Description 402-410
Aluminum is an
omnipresent neurotoxicant and has been associated with several
neuropathological disorders. Cerebrum and cerebellum have been shown to face
augmented oxidative stress when animals are exposed to aluminum and high doses
of ethanol. To establish the link between oxidative stress and neurobehavioral
alterations, the present study was conducted to determine the extent of
oxidative stress in low levels of pro-oxidant (ethanol exposure) status of the
functionally discrete regions of the cerebrum. Male Wistar rats were exposed to
aluminum (10 mg/kg body wt) and ethanol (0.2-0.6 g/kg body wt) for 4 weeks.
Spontaneous motor activity (SMA) and Rota-Rod performances (RRP) were recorded
weekly during the period of exposure. At the end of 4th week,
oxidative stress parameters were determined from the homogenized cerebral
tissue. GSH-independent superoxide peroxide handling capacity (GI-SPHC) and
GSH-dependent superoxide peroxide handling capacity (GD-SPHC) were determined
for FC and TC upon exposure to ethanol in the absence and presence of aluminum
exposure. Aluminum was found to augment the oxidative stress at higher doses
(0.6 g Ethanol/kg body wt) of ethanol, particularly in FC. The SPHC of FC was
also found to be compromised significantly in aluminum-ethanol co-exposed
animals. It was concluded that even though the manifestation of oxidative
stress was not observed as revealed by assaying the widely used oxidative
stress biochemical markers (indices), aluminum and ethanol (low doses) exposure
induced alterations in the handling capacity of oxidant imbalance that could be
recognized by studying the SPHC of FC. Comparison of GD-SPHC and GI-SPHC
offered a possible mechanism of compromised SPHC in FC. This observation is
likely to offer insights into the mechanism of association between aluminium
exposure and behavioral changes in neurodegenerative disorders towards
therapeutic strategies for these disorders.
 
Date 2013-10-26T09:48:01Z
2013-10-26T09:48:01Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22640
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]