Record Details

Impact of COMT H108L, MAOB int 13 A>G and DRD2 haplotype on the susceptibility to Parkinson’s Dise<span style="mso-ansi-language:EN-US" lang="EN-US">ase in South Indian subjects<span style="mso-ansi-language:EN-US" lang="EN-US"> </span></span>

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Impact of COMT H108L, MAOB int 13 A>G and DRD2 haplotype on the susceptibility to Parkinson’s Disease in South Indian subjects
 
Creator Kumudini, Nadella
Uma, Addepally
Devi, Yalavarthy Prameela
Naushad, Shaik Mohammad
Mridula, Rukmini
Borgohain, Rupam
Kutala, Vijay Kumar
 
Subject Parkinson’s disease
Dopamine
Catechol O-methyl transferase
Monoamine oxiadase
Dopamine receptors
Polymorphism
 
Description 436-441
In view of
documented evidence demonstrating the association of dopaminergic metabolism
and neurotransmission with Parkinson’s disease (PD), a case-control study was
conducted to investigate the impact of particular polymorphisms in the catechol
O-methyl transferase (COMT) H108L, monoamine oxidase B (MAOB) int 13 A>G,
dopamine transporter 1 (DAT1) A1215G, dopamine receptor D2 (DRD2) Taq1A, DRD2
Taq1B and DRD2 Taq1D genes on the susceptibility to PD.
PCR-RFLP method was used for the genetic analysis. The COMT H108L polymorphism
increased PD risk by 1.4-fold (95%CI: 1.02-1.98), whereas reduced risk was
observed with MAOB int 13 A>G polymorphism (OR: 0.77, 95%CI: 0.51-0.99).
Multifactor dimensionality reduction analysis showed gene-gene interactions
between these two loci that resulted in loss of the protective role of MAOB
G-allele in the presence of COMT L-allele. DAT1A1215G polymorphism in the exon
9 was not associated with PD. Individually, DRD2 polymorphisms showed null
association. However, all-variant haplotype of DRD2 locus i.e. T-G-T haplotype
showed 29.8-fold risk for PD compared to all-wild haplotype i.e., C-A-C
haplotype
(95%CI: 6.85-130.4). To conclude, genetic variants of COMT, MAOB and DRD2 loci
modulate susceptibility to PD in South Indian subjects.
 
Date 2013-10-26T09:51:40Z
2013-10-26T09:51:40Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22644
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]