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Cardiac risk factors in descendants of parents with history of coronary artery disease (CAD) : An evaluation focusing on small dense low density lipoprotein cholesterol (sdLDLc) and high density lipoprotein cholesterol (HDLc)

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Title Cardiac risk factors in descendants of parents with history of coronary artery disease (CAD) : An evaluation focusing on small dense low density lipoprotein cholesterol (sdLDLc) and high density lipoprotein cholesterol (HDLc)
 
Creator Sharma, Praveen
Purohit, Purvi
Gupta, Rashmi
 
Subject Coronary artery disease
Diabetes mellitus
Total cholesterol
HDL2c
HDL3c
HOMA-β
Insulin resistance
LbLDLc
sdLDLc
Metabolic syndrome
Phospholipid
Hypertension
Insulin
Triglycerides
Waist circumference
Waist hip ratio
 
Description 453-461
The risk of coronary artery disease (CAD) in
descendants with positive family history of CAD was evaluated in either one of
or both the parents among 71 selected families. Subjects were grouped as
parents and descendants without and with CAD and descendants spouses without
CAD or family history of CAD. All subjects were examined for anthropometric
characteristics, fasting blood sugar, serum lipids, lipoprotein sub-fractions,
insulin, insulin resistance and pancreatic beta cell function. The results were
subjected to statistical analysis by using the analysis of variance (ANOVA).
Metabolic syndrome (MetS) was prevalent in the 83% descendants with CAD and
54.6% parents with CAD. The traditional risk factors were observed in both
parents and descendants with CAD. Metabolic risk factors, including
hypertriglyceridemia, low HDLc levels and hyperglycaemia had a higher frequency
in the descendants with CAD. ANOVA showed significant ‘F’ ratio for the
anthropometric characteristics, hypertension, serum lipids, small dense (sd)
LDLc levels, HDL2c levels and HDL3c levels in the descendants parents with CAD
and CAD + diabetes mellitus (DM), as compared to those without CAD. The
descendants without CAD, but with a positive family history had central
adiposity, hypertension and had lower HDL levels and elevated sdLDLc levels.
Multiple analyses of variance showed that sdLDLc and waist circumference were
the most potent risk factors for prevalence of CAD. Thus, we conclude that a
positive family history of CAD along with central adiposity and elevation of
sdLDLc levels appear to be important factors in the assessment of CAD risk in
humans.


 
Date 2013-10-26T09:53:29Z
2013-10-26T09:53:29Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22646
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]