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Role of nitric oxide, angiogenic growth factors and biochemical analysis in preeclampsia

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Title Role of nitric oxide, angiogenic growth factors and biochemical analysis in preeclampsia
 
Creator Saha, Tanmay
Halder, Mrityunjoy
Das, Amitabha
Das, Subir Kumar
 
Subject Nitric oxide
Placental growth factor
Preeclampsia
Vascular endothelial growth factor
 
Description 462-466
Preeclampsia, a pregnancy-related
hypertensive disorder, is one of the leading causes of fetal and maternal mortality and
morbidity globally. Angiogenic growth factors, including vascular endothelial
growth factor (VEGF) and placental growth factor (PlGF) are involved in the
generation of new blood vessels required for placental development and
physiological functions, while nitric oxide (NO) acts as vasodilator and also
plays a role in angiogenesis. The objective of this study was to evaluate the
role of NO, angiogenic growth factors (VEGF and PIGF) and other biochemical
parameters in the development of preeclampsia among pregnant mothers. A complete clinical history, including anthropometric measurements
and biochemical investigations, including renal function tests, liver function
tests and lipid profile were performed among twenty preeclampsia patients
aged 19 to 32 yrs. Results were compared with age-matched normotensive pregnant
mothers. The body
weight, body mass index (BMI), blood pressure, concentrations of urea, uric
acid and triglyceride and activities of transaminase enzymes (aspartate
transaminase, AST and alanine transaminase, ALT) in serum were significantly
higher (p
 
Date 2013-10-26T09:54:17Z
2013-10-26T09:54:17Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22647
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]