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Autistic children exhibit distinct plasma amino acid profile

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Title Autistic children exhibit distinct plasma amino acid profile
 
Creator Naushad, Shaik Mohammad
Jain, Jamal Md Nurul
Prasad, Chintakindi Krishna
Naik, Usha
Akella, Radha Rama Devi
 
Subject Autism
Glutamate
Asparagine
Tryptophan
Methionine
 
Description 474-478
In order to ascertain whether autistic
children display characteristic metabolic signatures that are of diagnostic
value, plasma amino acid analyses were carried out on a cohort of 138 autistic
children and 138 normal controls using reverse-phase HPLC. Pre-column
derivatization of amino acids with phenyl isothiocyanate forms phenyl
thio-carbamate derivates that have a λmax of 254 nm, enabling their detection using photodiode array. Autistic children showed elevated levels of
glutamic acid (120 ± 89 vs. 83 ± 35 mmol/L) and asparagine (85 ± 37 vs.
47 ± 19 mmol/L); lower levels of phenylalanine (45 ± 20 vs. 59 ± 18 mmol/L), tryptophan (24 ± 11 vs.
41 ± 16 mmol/L), methionine (22 ± 9 vs. 28
± 9 mmol/L) and histidine (45 ± 21 vs. 58 ± 15 mmol/L). A low molar ratio of (tryptophan/large neutral amino acids)
× 100
was observed in autism (5.4 vs 9.2), indicating lesser availability of
tryptophan for neurotransmitter serotonin synthesis. To conclude, elevated
levels of excitatory amino acids (glutamate and asparagine), decreased
essential amino acids (phenylalanine, tryptophan and methionine) and decreased
precursors of neurotransmitters (tyrosine and tryptophan) are the distinct
characteristics of plasma amino acid profile of autistic children. Thus, such
metabolic signatures might be useful tools for early diagnosis of autism.


 
Date 2013-10-26T09:56:29Z
2013-10-26T09:56:29Z
2013-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/22649
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(5) [October 2013]