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Inhibitory effect of <i>Piper betle</i> Linn. leaf extract on protein glycation <span style="font-family:Symbol;mso-ascii-font-family:"Times New Roman";mso-hansi-font-family: "Times New Roman";mso-char-type:symbol;mso-symbol-font-family:Symbol" lang="EN-GB">- Quantification and characterization of the antiglycation components </span>

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Title Inhibitory effect of Piper betle Linn. leaf extract on protein glycation - Quantification and characterization of the antiglycation components
 
Creator Bhattacherjee, Abhishek
Chakraborti, Abhay Sankar
 
Subject Piper betle
Protein glycation
Advanced glycation end products
Diabetes mellitus
Rutin
 
Description 529-536
Piper betle Linn. is a Pan-Asiatic plant having
several beneficial properties. Protein glycation and advanced glycation end
products (AGEs) formation are associated with different pathophysiological
conditions, including diabetes mellitus. Our study aims to find the effect of methanolic extract of P.
betle leaves on in vitro
protein glycation in bovine serum albumin (BSA)-glucose model. The
extract inhibits glucose-induced glycation, thiol group modification and
carbonyl formation in BSA in dose-dependent manner. It inhibits different
stages of protein glycation, as demonstrated by using glycation models:
hemoglobin-d-gluconolactone (for early stage, Amadori product
formation), BSA-methylglyoxal (for middle stage, formation of oxidative
cleavage products) and BSA-glucose (for last stage, formation of AGEs) systems.
Several phenolic compounds are isolated from the extract. Considering their
relative amounts present in the extract, rutin appears to be the most active
antiglycating agent. The extract of P. betle leaf may thus have
beneficial effect in preventing protein glycation and associated complications
in pathological conditions.
 
Date 2013-12-27T11:48:15Z
2013-12-27T11:48:15Z
2013-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/25172
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(6) [December 2013]