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Association of Parkinson's disease with altered serum levels of lead and transition metals among South Indian subjects

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Title Association of Parkinson's disease with altered serum levels of lead and transition metals among South Indian subjects
 
Creator Kumudini, Nadella
Uma, Addepally
Devi, Yalavarthy Prameela
Naushad, Shaik Mohammad
Mridula, Rukmini
Borgohain, Rupam
Kutala, Vijay Kumar
 
Subject Parkinson’s disease
Iron
Copper
Lead
Manganese
Oxidative stress
 
Description 121-126
Several epidemiologic studies have suggested
an association between the Parkinson’s disease (PD) and exposure to heavy
metals, such as lead, iron, copper, manganese, etc. A growing body of evidence
suggests that heavy metals stimulate free radical formation in the brain and
can lead to neurodegeneration. In the present study, we investigated whether
such association exists in PD cases from rural and urban areas in our study
population. The plasma levels of copper, iron, manganese and lead in PD cases
(n = 150) and controls (n = 170) were determined by inductively coupled plasma mass
spectrometry (ICP-MS) and correlated with the oxidative stress markers like
malondialdehyde (MDA), protein carbonyl and total glutathione. Results
indicated significant increase in the levels of copper (17.73 ± 4.48 vs. 13.0 ±
3.22 ng/ml) and iron (554.4 ± 123.8 vs. 421.7 ± 126.1 ng/ml) in PD cases
compared to controls, whereas no significant differences in the levels of
manganese and lead were observed. Further, the data based on urban or rural
residence showed that plasma copper, iron, manganese levels were comparatively
higher in rural subjects, whereas plasma lead levels were significantly higher
in urban subjects. Increased plasma iron showed positive correlation with
marker of lipid peroxidation (MDA), suggesting that increased iron levels induced
oxidative stress in PD. These results substantiated the earlier observations
about the role of environmental exposure and metal-induced oxidative stress in
the etiology of PD.
 
Date 2014-04-30T06:42:03Z
2014-04-30T06:42:03Z
2014-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/28689
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(2) [April 2014]