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Ameliorative effect of septilin, an ayurvedic preparation against γ-irradiation-induced oxidative stress and tissue injury in rats

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Title Ameliorative effect of septilin, an ayurvedic preparation against γ-irradiation-induced oxidative stress and tissue injury in rats
 
Creator Mansour, Heba Hosny
Ismael, Naglaa El-Sayed Rifaat
Hafez, Hafez Farouk
 
Subject Septilin
γ-Radiation
Antioxidant
Tissue injury
 
Description 135-141
Ionizing radiation is known to induce multiple
organ dysfunctions directly related to an increase of cellular oxidative
stress, due to overproduction of reactive oxygen species (ROS). This study was aimed
to investigate the effect of septilin
(an ayurvedic poly-herbal formulation containing the principal herbs, namely Commiphora
wightii, Trinospora cordifolia, Rubia cardifolia, Emblica officinalis,
Saussurea lappa and Glycyrrhiza glabra) against whole body
γ-irradiation-induced oxidative damage in hepatic and brain tissues in rats.
Administration of septilin for 5 days (100 mg/kg) prior to radiation resulted
in a significant increase in both superoxide dismutase (SOD) activity and total
glutathione (GSH) level in hepatic and brain tissues, while serum high-density
lipoprotein-cholesterol (HDL) was reduced by γ-irradiation. Also, septilin
resulted in a significant decrease in NO(x), nitric oxide and malondialdehyde
(MDA) levels in hepatic and brain tissues and a significant decrease in serum
triglycerides, low-density lipoprotein-cholesterol (LDL) and total cholesterol
levels and serum alanine aminotransferase (ALT), aspartate aminotransferase
(AST) levels and alkaline phosphatase (ALP), γ-glutamyl transferase (GGT)
activities, as well as serum tumor necrosis factor-alpha (TNF-α), compared to
irradiated group. In conclusion, data obtained from this study indicated that
septilin exhibited potential antioxidant activity and showed radioprotective
effect against γ-radiation by preventing oxidative stress and scavenging free
radicals.
 
Date 2014-04-30T06:58:17Z
2014-04-30T06:58:17Z
2014-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/28691
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(2) [April 2014]