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Effect of gold nanoparticles on superoxide dismutase and indoleamine 2, 3-dioxygenase in various rat tissues

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Title Effect of gold nanoparticles on superoxide dismutase and indoleamine 2, 3-dioxygenase in various rat tissues
 
Creator Siddiqi, N J
 
Subject Gold nanoparticles
Superoxide dismutase
Indoleamine 2, 3 dioxygenase
 
Description 156-159
Gold
nanoparticles have diverse applications and are being used in food and cosmetic
industry, for drug delivery and in the diagnosis and treatment of cancer.
However there is a need to study their biochemical mode of action. In this
study, in vivo effect of gold nanoparticles on the activities of the two
antioxidant enzymes — superoxide dismutase (SOD) and indoleamine
2,3-dioxygenase (IDO) was investigated in various tissues of rats. Rats were
injected with 20 μg/kg body wt of 20 nm gold nanoparticles for three
consecutive days through intraperitoneal route. The animals were sacrificed by
CO2 asphyxiation 24 h after the last dose of gold nanoparticles.
Results showed that treatment with gold nanoparticles caused no significant change
in SOD activity in most of the tissues, except kidneys. In kidneys, gold
nanoparticles caused a significant increase in SOD activity, when compared to
the activity in control rats. However, treatment with gold nanoparticles
altered the expression pattern of SOD activity in various tissues. For example,
in control rats highest SOD activity was demonstrated in heart and least in
kidneys and spleen. But, in gold nanoparticles treated rats, maximum SOD
activity was observed in liver and the lowest in spleen. Gold nanoparticles
caused no significant change in IDO activity in the studied tissues.
 
Date 2014-04-30T07:01:58Z
2014-04-30T07:01:58Z
2014-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/28694
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(2) [April 2014]