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A study on human leukocyte antigen class I molecules in paediatric bronchial asthma

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Title A study on human leukocyte antigen class I molecules in paediatric bronchial asthma
 
Creator Mishra, Mahendra N
Dudeja, Puja
Gupta, Rakesh K
 
Subject Human leukocyte antigen class I
Paediatric bronchial asthma
Serum immunoglobulin E
 
Description 160-163
Childhood
asthma, often associated with atopy, is more common in boys and may persist
throughout life in 50% of cases. This case-control study was carried out to examine if any association of paediatric bronchial asthma with human
leukocyte antigen (HLA) class I antigens. Thirty-six children with bronchial
asthma diagnosed on basis of Global Initiative for Asthma (GINA) criteria and
an equal number of healthy controls without
history of bronchial asthma were studied. Low resolution
HLA- ABC typing was performed by sequence specific primers (SSP) and the
frequency of HLA–ABC antigens in the two groups was compared. Total serum
immunoglobulin E (IgE) estimation was done as a marker of atopy by ELISA. The
study included 24 boys and 12 girls aged 13 months to 11 yrs, of which 16 (44%)
had positive family history. Serum IgE levels were elevated in 20 (55%) of the
cases and 33% of controls with peak values of 4877 and 627 IU/ml, respectively.
No statistically significant correlation was observed between childhood asthma
and HLA class I antigens, however, a statistically significant correlation was
observed between serum IgE levels and asthma, which was elevated in cases, as
compared to normal population. Serum IgE levels did not show a linear trend, in
that a direct correlation with the severity of disease was not observed.
 
Date 2014-04-30T07:02:46Z
2014-04-30T07:02:46Z
2014-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/28695
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(2) [April 2014]