Record Details

Rutin ameliorates glycemic index, lipid profile and enzymatic activities in serum, heart and liver tissues of rats fed with a combination of hypercaloric diet and chronic ethanol consumption

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Rutin ameliorates glycemic index, lipid profile and enzymatic activities in serum, heart and liver tissues of rats fed with a combination of hypercaloric diet and chronic ethanol consumption
 
Creator Chuffa, Luiz Gustavo A
Fioruci-Fontanelli, Beatriz A
Bordon, Juliana G
Pires, Rafaelle B
Braga, Camila P
Seiva, Fábio R F
Fernandes, Ana Angélica H
 
Subject Rutin
Hypercaloric diet
Ethanol
Heart
Liver
Rat
 
Description 215-222
Alcoholism
and obesity are strongly associated with several disorders including heart and
liver diseases. This study evaluated the effects of rutin treatment in serum,
heart and liver tissues of rats subjected to a combination of hypercaloric diet
(HD) and chronic ethanol consumption. Rats were divided into three groups:
Control: rats fed a standard diet and drinking water ad libitum; G1:
rats fed the HD and receiving a solution of 10% (v/v) ethanol; and G2: rats fed
the HD and ethanol solution, followed by injections of 50 mg/kg-1
rutin as treatment. After 53 days of HD and ethanol exposure, the rutin was
administered every three days for nine days. At the end of the experimental
period (95 days), biochemical analyses were carried out on sera, cardiac and
hepatic tissues. Body weight gain and food consumption were reduced in both the
G1 and G2 groups compared to control animals. Rutin effectively reduced the
total lipids (TL), triglycerides (TG), total cholesterol (TC), VLDL,
LDL-cholesterol and glucose levels, while it increased the HDL-cholesterol in
the serum of G2 rats, compared to G1. Although rutin had no effect on total
protein, albumin, uric acid and cretinine levels, it was able to restore serum
activities of alkaline phosphatase (ALP), lactate dehydrogenase (LDH),
aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine
kinase (CK) in animals fed HD and receiving ethanol. Glycogen stores were
replenished in both hepatic and cardiac tissues after rutin treatment.
Moreover, rutin consistently reduced hepatic levels of TG and TC and cardiac AST,
ALT and CK activities. Thus, rutin treatment was effective in reducing the risk
factors for cardiac and hepatic disease caused by both HD and chronic ethanol
consumption.


 
Date 2014-07-14T05:54:51Z
2014-07-14T05:54:51Z
2014-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29087
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(3) [June 2014]