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Oxidative stress in patients with differentiated thyroid cancer: Early effects of radioiodine therapy

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Title Oxidative stress in patients with differentiated thyroid cancer: Early effects of radioiodine therapy
 
Creator Vrndic, Olgica B
Radivojevic, Snezana D
Jovanovic, Marina D
Djukic, Svetlana M
Teodorovic, Ljiljana C Mijatovic
Simonovic, Snezana T Zivancevic
 
Subject Differentiated thyroid cancer
Radioiodine therapy
Oxidative stress
Malondialdehyde
Uric acid
Total antioxidant status
 
Description 223-229
Ionizing radiation in differentiated thyroid cancer (DTC) patients
treated with radioiodine (131-I) produces reactive oxygen species (ROS), which
could induce oxidative stress with disturbance of redox balance. The aim of this study was
to evaluate
oxidative stress in DTC patients treated with 3.7 or 5.5 GBq of 131-I using values for serum malondialdehyde
(MDA, a marker of oxidative stress), uric acid (to determine antioxidant
status) and total antioxidative status (TAS). The study population included 20
DTC patients and 20 healthy controls. Significant differences in MDA concentrations were
found between DTC patients before 131-I therapy and control subjects (p = 0.001), while TAS
values were similar in both populations (p>0.05).
There was a negative correlation between MDA concentrations and TAS in the DTC
group before therapy (R2 = 0.2973, p = 0.013). Three days after
131-I therapy, MDA concentrations were higher than the pretreatment values (3.36 ± 1.69 nmol/mL vs. 2.93 ± 1.31 nmol/mL; p = 0.006),
while serum uric acid concentrations declined
progressively from 341.0
± 80.39 μmol/L to 304.25 ± 77.25 μmol/L (p = 0.026) in 3 days and 291.2 ± 88.86 μmol/L
(p = 0.009) in 7 days
after 131-I therapy. There was no dose-dependent effect on MDA, or uric acid
concentrations and TAS. Thus, 131-I therapy in DTC patients induced oxidative
stress, which was accompanied by a simultaneous and extended reduction in uric
acid concentration, but without significant disturbances in TAS. This
is the first study that evaluated TAS capacity in DTC patients before and 7
days after 131-I therapy. The relatively stabile TAS
values in these patients indicated a good protection from oxidative stress
induced by high doses of ionizing
radiation.


 
Date 2014-07-14T05:56:14Z
2014-07-14T05:56:14Z
2014-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29088
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(3) [June 2014]