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Fibrinogen, bFGF and VEGF levels during antibiotic therapy in gynecologic cancer: A preliminary report

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Title Fibrinogen, bFGF and VEGF levels during antibiotic therapy in gynecologic cancer: A preliminary report
 
Creator Palatyńska-Ulatowska, Aleksandra
Michalska, Marta
Łazarenkow, Andrzej
Nawrot-Modranka, Jolanta
Mirowski, Marek
Palatyński, Antoni
Jesionek-Kupnicka, Dorota
 
Subject bFGF
VEGF
Fibrinogen
Gynecological cancer
 
Description 230-236
The role of angiogenesis in the development of neoplasia has been identified and characterized. However, anti-angiogenic therapeutic
intervention still requires more evidence to become recognized and successful.
The aim of this study was to evaluate levels of selected proangiogenic factors,
such as fibrinogen, vascular endothelial growth factor (VEGF) and basic
fibroblast growth factor (bFGF) in serum of patients with the gynecologic
cancer on the first, third and sixth day of
antibiotic therapy, routinely administered as a perioperative treatment. In
addition, serum concentrations of γ-γ dimers and α-polymers of cross-linked fibrin
structure and the degree of bFGF binding with the fibrin network were
investigated. Immunohistochemistry staining of the excised tumor tissue was
also performed. We observed higher levels of bFGF, VEGF, as well as fibrinogen
in patients with gynecologic malignancy, as compared to healthy women. In
cancer patients, the concentration of α-polymers and γ-γ dimers
of fibrin network increased. Further only γ-γ dimers fraction of fibrin was found
to bind to bFGF. Immunohistochemical analysis indicated the presence of bFGF in
an excised tumor tissue. In conclusion, the decrease of proangiogenic bFGF and
fibrinogen levels in a clinical trial of gynecologic patients may confirm
anti-angiogenic properties of selected antibiotic therapy.
 
Date 2014-07-14T05:57:03Z
2014-07-14T05:57:03Z
2014-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29089
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(3) [June 2014]