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Amyloid ß lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity

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Title Amyloid ß lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity
 
Creator Madhavadas, Sowmya
Kutty, Bindu M
Subramanian, Sarada
 
Subject Amyloid ß
Acetylcholinesterase
Alzheimer disease
Monosodium glutamate
Obesity
Spatial memory
Ghrelin receptor analog [D-Lys (3)] GHRP-6
 
Description 257-262
Obesity arising
due to the dietary and life style changes is fast reaching epidemic proportions
all over the world. There is increasing evidence that the incidence of
Alzheimer disease (AD) is significantly influenced by a cluster of metabolic
diseases, including diabetes and obesity. This study was aimed to test the
suitability of experimentally-induced obesity in rats as an experimental animal
model of AD. We used the procedure of neonatal administration of rats with
monosodium
L-glutamate (MSG), which generates adult obese animals as our study design and
assessed the AD-like changes by measuring amyloid ß (1-42) and
acetylcholinesterase (AChE) levels in the hippocampal extracts and cognitive
impairments by Barnes maze task. Further, we investigated the influence of
anti-obesity substance [D-Lys (3)] GHRP-6 on blood glucose, hippocampal Aß,
AChE levels and restoration of cognitive deficits. Results revealed that
administration of MSG to neonatal rats exhibited increased body mass index and
serum glucose levels over the controls. Measurement of markers for AD-like
molecular changes i.e. amyloid ß (Aß) and AChE levels showed marked elevation
in these two parameters in the hippocampus of MSG-treated rats. Assessment of
cognitive abilities by Barnes maze revealed spatial disorientation
characteristic of AD. Administration of ghrelin receptor analog [D-Lys (3)]
GHRP-6 to obese rats resulted in significant restoration of serum cholesterol,
glucose, leptin and ghrelin levels to that of control with concomitant
reduction in hippocampal Aß and AChE levels. In addition, the treated animals
exhibited marked improvement in Barne’s maze task. These findings suggest that
MSG-induced obese rats may serve as non-transgenic animal model for AD
research. Further, the results indicate the potential of [D-Lys (3)] GHRP-6 as
a promising anti-Alzheimer candidate.
 
Date 2014-09-03T04:15:01Z
2014-09-03T04:15:01Z
2014-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29319
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(4) [August 2014]