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Association of polymorphisms G(–174)C in IL-6 gene and G(–1082)A in IL-10 gene with traditional cardiovascular risk factors in patients with coronary artery disease

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Title Association of polymorphisms G(–174)C in IL-6 gene and G(–1082)A in IL-10 gene with traditional cardiovascular risk factors in patients with coronary artery disease
 
Creator Elsaid, Afaf
Abdel-Aziz, A F
Elmougy, Rehab
Elwaseef, A M
 
Subject IL6 G/C Polymorphism
Coronary artery disease
Hyperlipidemia
Hypertension
 
Description 282-292
Interleukin-6
(IL-6) polymorphism has been associated with the genetic susceptibility to
coronary artery disease (CAD) and also with the lipid profile in different
populations. The present work aimed at studying the association, if any between
the IL-6 (174) G/C and IL-10 (1082) G/A genes with hypertension or
hyperlipidimia in Egyptian patients with CAD and the association of the IL-6
-174 G/C polymorphism with serum IL-6 levels. 108 Egyptian patients with CAD
and 143 unrelated healthy subjects were included in the study. The different
genotypes of IL-6 and IL-10 were detected by polymerase chain reaction. Serum
levels of lipoprotein(a) [Lp(a)] and IL-6 were estimated in the patients, as
well as in the healthy subjects. Increased frequency of G allele, GG and GC
genotypes in IL-6, as well as decreased frequency of C allele and CC genotype
were found in CAD patients, compared to healthy subjects [P = < 0.0001, OR =
3.95, 95% CI (2.16–7.22) for GG and GC vs CC genotype], [P = < 0.0001, OR = 3.44, 95% CI (2.26–5.23) for G allele]. There was an increased frequency of G allele vs A allele
in IL-10 genotype in CAD patients, compared to healthy subjects [P = 0.005, OR
= 1.866, 95% CI (1.2–2.9]. Higher levels of both Lp(a) and IL-6 were
observed in CAD patients, compared to control subjects (P = 0.0012, P = 0.0346,
respectively). Increased frequency of IL-6 -174
G-allele was implicated in a greater cardiovascular risk and the presence of G
allele or homozygosity for G allele of IL-10 G/A (1082) was associated with an
increased prevalence of CAD. The GC genotype and G allele in IL-6 had significant correlation with
hyperlipidimic CAD patients; however, G allele in IL-6 and IL-10 showed
significant association with hypertension. Thus, G allele in IL-6 and IL-10 was
considered as an independent risk factor in hypertensive CAD patients.
 
Date 2014-09-03T04:17:59Z
2014-09-03T04:17:59Z
2014-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29322
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(4) [August 2014]