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Fenthion, an organophosphorus pesticide, induces alterations in oxidant/antioxidant status and histopathological disorders in cerebrum and cerebellum of suckling rats

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Title Fenthion, an organophosphorus pesticide, induces alterations in oxidant/antioxidant status and histopathological disorders in cerebrum and cerebellum of suckling rats
 
Creator Amara, Ibtissem Ben
Sefi, Mediha
Troudi, Afef
Soudani, Nejla
Boudawara, Tahia
Zeghal, Najiba
 
Subject Fenthion
Neurotoxicity
Suckling rats
Cerebrum
Cerebellum
Pycknotic neurons
Apoptotic cells
Oxidative stress
 
Description 293-301
Fenthion
(FEN) is an organophosphorus pesticide known for its wide toxic manifestations.
In this study, the effects of FEN were evaluated on the cerebrum and cerebellum
oxidant/antioxidant status and histopathological disorders in the suckling
rats. Pregnant rats were divided into two groups: control group received pure
water, while FEN group received daily by
their drinking water 551 ppm of FEN from the 14th day of pregnancy
until day 14 after delivery. Acetylcholine esterase
(AChE) activity was
inhibited in both the cerebrum and cerebellum of suckling rats whose mothers
were treated with FEN. The cerebrum and cerebellum oxidative damage was
demonstrated by a significant increase of malondialdehyde (MDA), advanced
oxidation protein product and glutathione (GSH) levels and disturbance in the
antioxidant enzyme activities. A significant decline of non-protein thiol and
vitamin C levels was also observed. These changes were confirmed by histopathological observations which were marked by pyknotic neurons
in the cerebrum and apoptotic cells in the cerebellum of FEN-treated
rats. In the cerebellum of FEN-treated rats, the most conspicuous damage
was the absence of external granular layer, indicating growth retardation. These data suggested
that exposure of pregnant and lactating rats to FEN induced oxidative
stress and histopathological disorders in the cerebrum and cerebellum of their
pups. Thus, the use of FEN must be under strict control, especially for pregnant and lactating
mothers.
 
Date 2014-09-03T04:19:04Z
2014-09-03T04:19:04Z
2014-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29323
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(4) [August 2014]