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Anti-fatigue effects of polysaccharides extracted from <i style="mso-bidi-font-style:normal">Portulaca oleracea </i>L.<i style="mso-bidi-font-style:normal"> </i>in mice

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Title Anti-fatigue effects of polysaccharides extracted from Portulaca oleracea L. in mice
 
Creator Xu, Zhongxin
Shan, Ying
 
Subject Polysaccharides
Portulaca oleracea L.
Fatigue
Riding times
Exhaustive swimming times
Blood lactic acid
Serum urea nitrogen
Glycogen
 
Description 321-325
Portulaca
oleracea L. has been used as a food and medicinal
plant for thousands of years in China. Polysaccharides extracted from P. oleracea L. (POP) are its main
bioactive compound and have multiple pharmacological activities. However,
anti-fatigue effects of POP have not yet been tested. This study was designed
to investigate the anti-fatigue effects of POP in mice using the rotarod and
forced swimming tests. The mice were randomly divided into four groups, namely
normal control group, low-dose POP supplementation group, medium-dose POP
supplementation group and high-dose POP supplementation group. The normal
control group received distilled water and the supplementation groups received
different doses of POP (75, 150 and 300 mg/kg, respectively). The POP or
distilled water was administered orally and daily for 30 day. After 30 days,
the rotarod and forced swimming tests were performed and then several
biochemical parameters related to fatigue were determined. The data showed that POP prolonged the riding times and
exhaustive swimming times of mice, decreasing blood lactic acid and serum urea
nitrogen levels, as well as increasing the liver and muscle glycogen contents.
These results indicated that POP had
the anti-fatigue effects.
 
Date 2014-09-03T04:22:50Z
2014-09-03T04:22:50Z
2014-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29327
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(4) [August 2014]