Record Details

<i style="mso-bidi-font-style:normal">In silico</i> analysis of the structure and interaction of COP1 protein of <i style="mso-bidi-font-style:normal">Arabidopsis thaliana</i>

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title In silico analysis of the structure and interaction of COP1 protein of Arabidopsis thaliana
 
Creator Karumuri, Sudha
Bandopadhyay, Rajib
 
Subject COP1 protein
COP1 protein
In silico
Docking
Regulatory proteins
SPA1 protein
 
Description 343-349
Previous
studies have shown that COP1 (constitutive photomorphogenic 1) protein of Arabidopsis thaliana plays a crucial
role in different aspects of photomorphogenesis. Interaction of COP1 with SPA1
(suppressor of phytochrome A) and other regulatory proteins actively
affect light regulatory gene expression in diverse directions. Though several
studies have explained the function of COP1 protein, method of its interaction
with SPA1 and cryptochromes are still not explained in detail. In this study, in silico analysis was followed to
predict the tertiary structure, active site residues, functionally important
regions and regular expressions of COP1 protein. Its ease of its interaction
with SPA1 and seven other regulatory proteins, namely bZIP transcription factor
56 (HY5), transcription factor HY5-like (HYH), serine/threonine-protein
phosphatase 7 (AtPP7), protein long hypocotyl in FAR-RED 1 (HFR1),
OBP3-responsive protein 1 (OBP3), transcription factor MYC2 (MYC2/ZBF1) and
Z-box binding factor 2 protein (GBF1/ZBF2) was measured using protein-protein
docking. Interaction with MYC2 was found to be stronger than with others with a
global energy value of -22.46. It was also found that COP1 shared three regions
of regular expression with SPA1, the last expression also being present in
MYC2/ZBF1 and OBP3. Taken together, the insight into structural and functional
properties of COP1 protein presented in this study would be helpful in
determining the role of COP1 in unknown mechanisms of photomorphogenesis.
 
Date 2014-11-12T11:06:21Z
2014-11-12T11:06:21Z
2014-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/29891
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(5) [October 2014]