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Isoproterenol ameliorates workstress-induced rat skeletal muscle degeneration

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Title Isoproterenol ameliorates workstress-induced rat skeletal muscle degeneration
 
Creator Garg, Asha
Sharma, Sushma
 
Subject Isoproterenol
Butoxamine
Lipids
Work stress
 
Description 82-87
β-Agonists though have been widely studied for
their protein anabolic effects in skeletal muscles, but the lipid status under
work stress and agonist treatment have not been understood well in the skeletal
muscles and heart of rat. In the present

study, adult male Wistar rats were subjected to work
overload stress and β agonist isoproterenol treatment (2 mg kg-1 day-1
intraperitoneally) to examine, whether it attenuates work stress-induced
changes or not. Simultaneously, β2 antagonist

butoxamine (2 mg kg-1  day-1  intraperitoneally) was administered to another
isoproterenol-treated group. Work stress led to myofibrillar degeneration as well
as rapid utilization of lipid to meet increased energy demands and for muscle repair,
which was reflected through histochemical localization of lipids and biochemical
estimation of cholesterol and triglycerides. Significantly decreased cholesterol
levels in skeletal muscles and heart muscles were noticed. As expected, isoproterenol

reversed the conditions by raising cholesterol and
triglyceride levels significantly in the skeletal muscles and also by ameliorating
the degenerative changes in muscle fibres as induced by work overload. However,
severe accumulation of lipids in heart infers towards deleterious effects of isoproterenol
on heart and thus remains a limiting factor for its immediate clinical application.
Further research is needed to separate desirable effects of  β agonists on skeletal muscles from any undesirable
effects on the heart, so as to optimize their therapeutic potential.
 
Date 2015-01-07T07:05:05Z
2015-01-07T07:05:05Z
2006-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30310
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.43(2) [April 2006]