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Exploring selectivity requirements for peripheral versus central benzodiazepine receptor bindingaffinity: QSAR modeling of 2-phenylimidazo[1,2-a]pyridine acetamides using topological and physicochemical descriptors

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Title Exploring selectivity requirements for peripheral versus central benzodiazepine receptor bindingaffinity: QSAR modeling of 2-phenylimidazo[1,2-a]pyridine acetamides using topological and physicochemical descriptors
 
Creator Dalai, Manoj Kumar
Leonard, J Thomas
Roy, Kunal
 
Subject Quantitative structure-activity relationship
Peripheral and central benzodiazepine receptor binding
2-phenyli midazo[ 1,2-a]pyridineacetamides
 
Description 105-118
Considering the potential of peripheral benzodiazepine
receptor (PBR) Jigands in therapeutic applications and clinical benefit in the
management of a large spectrum of different indications, quantitative structure-activity
relationship (QSAR)

study has been attempted to explore the structural
and physicochemical requirements for selectivity of 2-phenylimidazo[1,2- a]pyridineacetamides
for binding with peripheral over central benzodiazepine receptors (CBRs). For
PBR binding affinity,

molar refractivity (MR) shows a
parabolic relation with binding affinity suggesting that binding affinity
increases with increase in volume of the compounds, until it reaches the critical
value, after which the affinity decreases. …
 
Date 2015-01-07T07:05:49Z
2015-01-07T07:05:49Z
2006-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30311
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.43(2) [April 2006]