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Oxidative stress in tumour-bearing fore-stomach and distant normal organs of Swiss albino mice

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Title Oxidative stress in tumour-bearing fore-stomach and distant normal organs of Swiss albino mice
 
Creator Gagandeep
Rao, A R
Kale, R K
 
Subject Fore-stomach tumour
Oxidative stress
Antioxidant enzymes
Carcinogen metabolizing enzymes
Benzo(a)pyrene
cytochrome P450 system
 
Description 216-221
Antioxidant status in the tumour-bearing
fore-stomach and distant normal organs (liver, spleen, kidney and heart) was investigated
in Swiss albino mice. In addition, the cytochrome P450 (cyt P450)
system was also examined in the liver. Benzo(a)pyrene [B(a)p] (8 doses of 1 mg/0.l ml) was administered twice a week for 4 weeks to
develop fore-stomach tumour. The animals were sacrificed at the end of 140
days. The specific activities of catalase (CAT), DT-diaphorase (DTD) and
glutathione-S-transferase (GST) were found decreased, and the level of reduced
glutathione (GSH) and the specific activity of lactate dehydrogenase (LDH)
increased in the tumour-bearing fore-stomach; however, no change was observed
in superoxide dismutase (SOD) activity. The specific activities of antioxidant
enzymes, and levels of GSH were also altered in the normal organs, depending
upon the type of tissue. In addition, the contents of cyt P450 and
cyt b5. and the activity of NADPH cyt P450 reductase were
significantly decreased in the fiver. The results suggest increased oxidative
stress in the tumour, and disturbance in the cooperative antioxidant functions
in the distant normal organs. Inhibition of cyt P450 system reflected
the possible adverse effect on drug metabolism function of the liver. Since,
the antioxidant potential and the drug metabolism function were altered, the
findings may have relevance to the radiation and chemotherapy of cancer.


 
Date 2015-01-16T11:37:30Z
2015-01-16T11:37:30Z
2005-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30383
 
Language en_US
 
Relation C07M 3/00
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.42(4) [August 2005]