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Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats

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Title Evaluation of hepatoprotective potential of propolis extract in carbon tetrachloride induced liver injury in rats
 
Creator Shukla, Sangeeta
Bhadauria, Monika
Jadon, Anjana
 
Subject Propolis
Hepatoprotective activity
Rat
Carbon tetrachloride
Oxidative stress
Liver function
 
Description 321-325
Propolis (bee glue), a resinous wax-like beehive
product has been used since ancient times for its pharmaceutical properties. In
the present study, the ethanolic extract of propolis (50, 100, 200 and 400
mg/kg, p.o.) was studied for its hepatoprotective
activity against carbon tetrachloride (CC14, 1.5 ml/kg, i.p.) induced liver damage in rats. Administration of
CCl4 caused a sharp elevation in the activity of serum
transaminases, serum alkaline phosphatase, acid phosphatase and hepatic lipid
peroxidation (LPO) levels, and a significant decrease in the ATPase, alkaline

phosphatase and succinic dehydrogenase activities
in the liver and kidney and hepatic GSH level. The treatment with propolis
extract at the doses of 200 and 400 mg/kg significantly reversed the various
biochemical alterations in blood, liver and kidney induced by CCl4
intoxication. The hepatoprotective property of propolis maybe due to its
antioxidant activity.


 
Date 2015-01-16T11:42:24Z
2015-01-16T11:42:24Z
2005-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30389
 
Language en_US
 
Relation A61P1/16; C11D3/16
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.42(5) [October 2005]