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An insight into molecular mechanism of endocytosis

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Title An insight into molecular mechanism of endocytosis
 
Creator Neekhra, Nidhi
Padh, Harish
 
Subject Endocytosis
Receptors
Pinocytosis
Phagocytosis
Endosomes
Clatbrin
Adaptor proteins
Coatomer proteins
 
Description 69-80
Endocytosis involving pinocytosis, phagocytosis
and receptor-mediated pathway is a central process involved in numerous
cellular events: receptor recycling, nutrient uptake, transcytosis, antigen
processing and presentation, pathogen uptake etc. Traditionally, the process
has been studied using uptake kinetics and immunocytochemistry. In last few
decades, additional tools, like mutant analysis, density shift, semi-intact and
cell-free systems and electromagnetic separation have

helped us to obtain molecular insight into many of
the' steps involved in endocytosis. New chemical entities, like clathrin and coatomer
proteins involved in internalization have been fully characterized.
Biomolecules involved in vesicle budding diffusion reactions, like ARF (ADP
ribosylation factors), COPs (coal proteins), and SNAREs (soluble
N-ethylmaleimide sensitive factor attachment protein receptors) have been
identified and characterized. Compartment specific molecules, like Rab have
also added to our understanding of complex process of endocytosis. Collectively
these have led us to an era of molecular endocytosis. The present review gives
an overview of the process and describes some of the molecular events of the
endocytic process. It also describes methods and approaches used in deciphering
the events at cellular and molecular levels.
 
Date 2015-01-16T11:49:22Z
2015-01-16T11:49:22Z
2004-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30392
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.41(2&3) [April-June 2004]