Record Details

Implications of Fundamental Signalling Alterations in Diabetes mellitus-associated Cardiovascular Disease

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Implications of Fundamental Signalling Alterations in Diabetes mellitus-associated Cardiovascular Disease
 
Creator Balakumar, Pitchai
 
Subject Diabetes mellitus
Signalling alterations
Cardiovascular disease pathology
 
Description 441-448
The chronic diabetes mellitus (DM) is a
major risk factor for cardiovascular disease. The incidence of cardiovascular
disease might be a foremost cause of morbidity and mortality in patients
afflicted with DM. In fact, DM is associated with multi-factorial cardiovascular
signalling alterations via significant modulation of expression pattern,
activation or release of PI3K, PKB, eNOS, EDRF,
NADPH oxidase, EDHF, CGRP, adenosine, iNOS,
ROCK, PKC-β2, CaMKII, microRNA (miR)-126 and miR-130a, which
could result in inadequate maintenance of cardiovascular physiology and
subsequent development of cardiovascular pathology. This review highlights the
possible adverse implications of fundamental cardiovascular signalling
alteration in DM-associated cardiovascular disease pathology.
 
Date 2015-02-11T04:18:22Z
2015-02-11T04:18:22Z
2014-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30492
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(6) [December 2014]