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Insulin Signaling Network in Cancer

NOPR - NISCAIR Online Periodicals Repository

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Title Insulin Signaling Network in Cancer
 
Creator Ray, Alpana
Alalem, Mohamed
Ray, Bimal K
 
Subject Insulin
Insulin-like growth factors
Insulin receptors
IGF-R
Insulin-like growth factor receptor
Insulin receptor substrate
PI3 kinase
Akt
GLUT4
mTOR
 
Description 493-498
The primary function of
insulin is viewed as a hormone that controls blood glucose level. However,
there is growing evidence that aberrant insulin level and insulin-mediated
signaling can lead to cancer development and progression.
The insulin-cancer relationship has stemmed from various observational and
epidemiological studies, which linked higher incidence of cancer with central
obesity, type II diabetes and other conditions associated with increased levels
of circulating insulin, insulin resistance and hyperinsulinemic states.
Increased risk of developing a range of cancers is also seen with a certain
treatment options used to lower blood glucose level in diabetic patients. While
metformin monotherapy has the lowest risk of developing cancer, in comparison,
treatment with insulin or insulin secretagogues shows more likelihood to
develop solid cancers. Cellular signaling initiated by insulin provides a clue
regarding these diverse cellular outcomes.
This review discusses how the insulin enacts such diverse physiological effects
and the insulin-cancer relationship,
with focus on the role of insulin signaling in cancer.
 
Date 2015-02-11T04:24:42Z
2015-02-11T04:24:42Z
2014-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30498
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(6) [December 2014]