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Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells

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Title Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells
 
Creator Das, Siddhartha
Martinez, Leobarda Robles
Ray, Suparna
 
Subject Colon cancer
Arachidonic acid
Lipid remodeling
Cyclooxygenase
Lipooxygenase
Prostaglandins
Leukotrienes
 
Description 512-519
Phospholipid remodeling and eicosanoid
synthesis are central to lipid-based inflammatory reactions. Studies have
revealed that membrane phospholipid remodeling by fatty acids through
deacylation/reacylation reactions increases the risk of colorectal cancers
(CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as
prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have
been made to understand the lipid remodeling pathways and to design anti-cancer
drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the
recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.
 
Date 2015-02-11T04:29:52Z
2015-02-11T04:29:52Z
2014-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30501
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(6) [December 2014]