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Herbicide paraquat induces sex-specific variation of neuroinflammation and neurodegeneration in <i>Drosophila melanogaster</i>

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Title Herbicide paraquat induces sex-specific variation of neuroinflammation and neurodegeneration in Drosophila melanogaster
 
Creator Dalui, Shauryabrota
Bhattacharyya, Arindam
 
Subject Paraquat
Drosophila
Neurodegeneration
Pro-inflammatory factors
 
Description 567-573
There are
several reports on herbicide paraquat (PQ)-induced Parkinsonian-like pathology
in different animal models, including Drosophila
melanogaster. Also, the role of some inflammatory factors, such as nitric
oxide is reported in
PQ-induced neuroinflammation of Drosophila. Although invertebrate model
is valuable to study the conserved inflammatory pathway at the time of
neurodegeneration, but neuroinflammation during PQ-mediated neurodegeneration has
not been studied explicitly in Drosophila.
In this study, the inflammatory response was examined in Drosophila model during PQ-induced neurodegeneration. We found that
after exposure to PQ, survivability and locomotion ability were affected in
both sexes of Drosophila. Behavioural
symptoms indicated similar physiological features of Parkinson’s disease (PD) in
different animal models, as well as in humans. Our study revealed alteration in
proinflamatory factor, TNF-α and Eiger
(the Drosophila homologue in
TNF superfamily) was changed in
PQ-treated Drosophila both at protein and mRNA level during
neurodegeneration. To ensure the occurrence of neurodegeneration, tyrosine
hydroxylase (TH) positive neuronal cell loss
was considered as a hallmark of PD in the fly brain. Thus, our result revealed
the conserved inflammatory events in terms
of expression of TNF-α and Eiger
present during a sublethal dose of PQ-administered neurodegeneration in male
and female Drosophila with significant variation in proinflamatory factor
level among both the sexes.
 
Date 2015-02-11T04:47:21Z
2015-02-11T04:47:21Z
2014-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/30508
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.51(6) [December 2014]