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Serum neuron-specific enolase and S-100β levels as prognostic follow-up markers for oxygen administered carbon monoxide intoxication cases

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Title Serum neuron-specific enolase and S-100β levels as prognostic follow-up markers for oxygen administered carbon monoxide intoxication cases
 
Creator Yildirim, Ali Osman
Eroglu, Murat
Kaldirim, Umit
Eyi, Yusuf Emrah
Simsek, Kemal
Durusu, Murat
Yamanel, Levent
Arziman, Ibrahim
Tuncer, Salim Kemal
Toygar, Mehmet
Balkan, Arzu
Cayci, Tuncer
Demirbas, Seref
Oter, Sukru
Bilgi, Cumhur
 
Subject Brain injury
Carbon monoxide poisoning
Hyperbaric oxygen
Neuron-specific enolase
Oxygen therapy
S-100β
 
Description 29-33
Serum neuron-specific
enolase (NSE) and S-100β levels are considered novel biochemical markers of
neuronal cell injury. In this study, the
initial and post-treatment levels of NSE and S-100β were compared in carbon
monoxide (CO) poisoning patients, who received normorbaric oxygen (NBO) or
hyperbaric oxygen (HBO) therapy. Forty consecutive patients with acute CO
poisoning were enrolled in this prospective, observational study.
According to their clinical symptoms and observations, twenty patients were
treated with NBO, and the other twenty with HBO. Serum S-100β and NSE levels
were measured both at time of admission and 6 h later (post-treatment).
Serum NSE and S-100β values decreased significantly in both of the therapeutic
modalities. The initial and post-treatment values of NSE and S-100β in NBO or
HBO patients were comparable. A clear negative correlation was observed between
the decrease of NSE and
S-100β levels and initial blood carboxyhemoglobin levels. In conclusion, the
present results suggested the use of serum
S-100β and NSE levels as indicators for brain injury. Due to the significant
increase of their values with oxygen therapy, they may also be useful as
prognostic follow-up markers. However, the current findings reflected no
difference between the efficacy of NBO or HBO therapy.
 
Date 2015-03-30T05:29:26Z
2015-03-30T05:29:26Z
2015-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/31270
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.52(1) [February 2015]