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Angiotensin II inhibits Na<sup>+</sup>/K<sup>+</sup>ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein

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Title Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein
 
Creator Rahaman, Sayed Modinur
Dey, Kuntal
Chakraborti, Tapati
Chakraborti, Sajal
 
Subject Pulmonary artery smooth muscle cells
Oxidant
Glutathionylation
Na+/K+-ATPase
Na+/K+ATPase inhibitor
 
Description 119-124
The role of angiotensin II in regulating Na+/K+-ATPase
activity has been investigated in bovine pulmonary artery smooth muscle cells
(BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase
activity via glutathionylation of the pump with the involvement of an increase
in NADPH oxidase-derived O2.-. Additionally, angiotensin
II treatment to the cells increases the inhibitory potency of the 15.6 kDa
inhibitor towards the Na+/K+ATPase activity.
 
Date 2015-05-14T11:10:45Z
2015-05-14T11:10:45Z
2015-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/31521
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.52(2) [April 2015]