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<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:SimSun;mso-bidi-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">Up-regulation of NLRC5 and NF-кB signaling pathway in carrier chickens challenged with <i style="mso-bidi-font-style:normal">Salmonella enterica</i> Serovar Pullorum at different persistence periods </span>

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Title Up-regulation of NLRC5 and NF-кB signaling pathway in carrier chickens challenged with Salmonella enterica Serovar Pullorum at different persistence periods
 
Creator Liu, Xiangping
Ma, Teng
Wang, Hongzhi
Sheng, Zhongwei
Dou, Xinhong
Wang, Kehua
Li, Zhiteng
Pan, Zhiming
Chang, Guobin
Chen, Guohong
 
Subject Chicken
S. Pullorum
Immune performance
SNPs
Candidate gene
Expression
 
Description 132-139
The
immune performance, SNPs and expression levels of
candidate genes (IL1-β, Nramp1, TLR4,
MyD88, NF-кB and NLRC5)
were analyzed in carrier chickens of a Chinese indigenous breed infected with Salmonella enterica Serovar Pullorum at different persistence periods (12,
19 and 24 weeks of age). Carrier birds at 19 weeks of age presented significant
difference in most immune parameters, as compared to carriers at 12 and 24
weeks of age, while no significant difference in most immune parameters was
observed between carriers at 12 and 24 weeks of age. The genotype distributions
of IL1-β and TLR4 presented significant differences
between carriers and healthy birds. The expression levels of most candidate
genes in carriers at 19 weeks of age were significantly higher than that in
carriers at 12, 24 weeks of age and healthy birds and reached 1% level of
significance between carriers at 19 weeks of age and healthy birds. The
expression patterns of all genes, but IL-1β and NLRC5 between
carriers at 12 and 24 weeks of age in all tissues were similar. Compared with
carriers at
12 weeks of age, IL1-β was significantly down-regulated, but NLRC5
was significantly up-regulated in carriers at 24 weeks of age. Our study
demonstrated that immune performance of carrier birds was severely impaired at
age of sexual maturation and NLRC5 might play as a negative mediator of NF-кB
pathway involved in immune response to asymptomatic infection by S. Pullorum.
The TLR4/MyD88/NF-кB
pathway might be suitable for study on S. Pullorum infection in
Chinese indigenous breeds.


 
Date 2015-05-14T11:13:54Z
2015-05-14T11:13:54Z
2015-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/31523
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.52(2) [April 2015]