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Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study

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Field Value
 
Title Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study
 
Creator Miao, Xingyu
Wu, Xiaoying
Shi, Wei
 
Subject Neurological diseases
Umbilical cord mesenchymal stem cells
Stem cell
Intrathecal administration
Lumbar puncture
 
Description 140-146
We investigated the intrathecally administrated unbilical
cord mesenchymal stem cells (UC-MSCs) by lumbar
puncture and assessed the technical difficulties and effects in
various neurological
conditions. One hundred patients
underwent subarachnoid placement of UC-MSCs between December 2006 and
May 2010 in the
Affiliated Hospital of Medicine. Technical difficulties in patients in the form of localization of subarachnoid
space, number of attempts, and post-procedural complications were evaluated.
Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem
cell transplant team on a regular basis. All patients were
followed-up for more than 1 yr after the treatment. Clinical symptoms, related
biochemical index and photographic examinations were observed regularly. We
encountered technical difficulties in 31 patients (31%) in the form
of general anesthesia supplementation and difficulty localizing the
lumbar space. Side effects (headache, low-grade fever, low back pain and lower limb
pain)
were observed in 22 (22%) patients, which were treated with symptomatic therapy
within 48 h. One year after the treatment, functional indices improved in 47
patients (47%): 12 patients with spinal cord injury,
11 patients with cerebral palsy, 9 patients with post-traumatic
brain syndrome, 9 patients with post-brain infarction syndrome, 3 patients with spinocerebellar ataxias, and 3 patients with motor neuron disease. In
conclusion,intrathecal administration
of UC-MSCs is
a safe and effective way to treat neurological disorders. Our
encouraging results of intrathecal administration of
UC-MSCs indicate the potential of restoration of lost tissue and improvement of
function in patients with profound neurological defects and inefficient
conventional cure. These data support expanded
double-blind, placebo-controlled studies for this treatment modality.
 
Date 2015-05-14T11:17:29Z
2015-05-14T11:17:29Z
2015-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/31524
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.52(2) [April 2015]