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Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy

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Title Vascular endothelial growth factor insertion/deletion gene polymorphism in West Indian patients of type 2 diabetes and diabetic nephropathy
 
Creator Dabhi, Brijesh
Mistry, Kinnari N
Patel, Hitesh
Lal, Sanjay
 
Subject Diabetic nephropathy
Polymorphism
Genotyping
VEGF gene
 
Description 209-212
Diabetic
nephropathy (DN) is a major cause of morbidity and mortality in diabetes.
Vascular endothelial growth factor (VEGF) is a potent multi-functional cytokine
which plays a key role in the pathogenesis of DN. In this study, we evaluated
the possible association of the VEGF gene (I/D) polymorphisms with DN in type 2
diabetes patients in West Indian population. Genotyping (I/D) of the VEGF gene
polymorphism was done by the polymerase chain reaction. A total of 103 patients
with type 2 diabetes,
102 patients with DN, 108 patients with non-diabetic nephropathy and 143
healthy controls were genotyped. The frequency of VEGF genotype distribution
and biochemical parameters like creatinine and HbA1c were compared in diabetic,
diabetic nephropathy, non diabetic nephropathy and control groups. We found
significant difference in creatinine level in DN and NDN groups on comparison
with control group. Our study suggests that I/D polymorphism in the promoter
region of the VEGF gene is not associated with DN in type 2 diabetes patients,
but might have a role in development of non-diabetic nephropathy.
 
Date 2015-05-14T11:44:40Z
2015-05-14T11:44:40Z
2015-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/31533
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.52(2) [April 2015]