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Pharmacogenomics: Translating functional genomics to personalized medicine

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Field Value
 
Title Pharmacogenomics: Translating functional genomics to personalized medicine
 
Creator Rajkumar, Shalini
 
Subject pharmacogenomics
gene polymorphism
SNP
DNA sequencing
functional genomics
 
Description 449-455
The emergence of human genome project brings hope of personalized medicine as patients with identical clinical symptoms may respond differently to the same drug therapy. Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors and other drug targets have been linked to differences in the efficacy and toxicity of many drugs between two individuals. Pharmacogenomics is the study of genetic factors that mediate a person’s drug response. Pharmacogenomic analysis promises to identify disease susceptibility genes thus discovering new drug targets. This may lead to an individualized application for drug therapy and bring new insights into disease prevention. The emerging discipline of pharmacogenomics attempts to apply the innovative technologies of genome sequencing in order to better understand drug response to produce more effective drugs with fewer side effects on the basis of individual patient’s genetic make up and making personalized medicine an economically viable possibility.
 
Date 2009-07-23T12:19:53Z
2009-07-23T12:19:53Z
2007-10
 
Type Article
 
Identifier 0975-0967 (Online); 0972-5849 (Print)
http://hdl.handle.net/123456789/5537
 
Language en_US
 
Relation Int. Cl.8 C12N15/00, 15/10
 
Publisher CSIR
 
Source IJBT Vol.6(4) [October 2007]