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<strong>Ultrasonic and viscometric study of molecular interactions of antibiotic doxycycline hycalte</strong>

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Title Statement <strong>Ultrasonic and viscometric study of molecular interactions of antibiotic doxycycline hycalte</strong>
 
Added Entry - Uncontrolled Name Kumar, R. ; The New College
Mohamed Kamil, M. G. ; The New College
Shri Prasad, S. ; The New College
Gayathri, G. S. ; The New College
Shabeer, T. K. ; The New College
 
Uncontrolled Index Term ultrasonic; Pharmaceutical; molecular physics
Ultrasonic velocity - DSV - dimerization - interaction - stacking – structure change
 
Summary, etc. Dilute solution viscometric (DSV) and ultrasonic techniques are employed to investigate the aqueous solutions of antibiotic doxycycline hyclate for different molar concentrations around the physiological temperatures. The viscometric Huggin’s plots and interaction parameter identify the existence of dimerization of doxycycline at 303.15 K and the dominance of solute-solvent interaction at higher temperatures. The ultrasonic velocity and the thermo acoustic parameters confirm the results obtained by DSV. For further confirmation of dimerization, the stacking parameter (D) was obtained through the Hemme’s isodesmic model. The values of ‘D claim the dimerization of doxycycline at ambient temperature and dissociation among the antibiotic molecules at 308.15 and 313.15 K. The ultrasonic velocity derivative limiting slope (A) claims solute-solute and solute-solvent interactions at ambient and elevated temperatures, respectively. The stacking constant (<em>K</em>) decreases with increase of temperature. The structure change of solvent is discussed.
 
Publication, Distribution, Etc. Indian Journal of Pure & Applied Physics (IJPAP)
2016-06-10 12:52:15
 
Electronic Location and Access binary/octet-stream
http://op.niscair.res.in/index.php/IJPAP/article/view/401
 
Data Source Entry Indian Journal of Pure & Applied Physics (IJPAP); ##issue.vol## 51, ##issue.no## 10 (2013): Indian Journal of Pure & Applied Physics
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJPAP/article/download/401/900
 
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