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Solubility enhancement of <em>Boswellia serrata</em> Roxb. ex Colebr. extract through a self dispersible lipidic formulation approach

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Title Statement Solubility enhancement of <em>Boswellia serrata</em> Roxb. ex Colebr. extract through a self dispersible lipidic formulation approach
 
Added Entry - Uncontrolled Name Bhardwaj, Anshuman ; Babu Banarsi Das National Institute of Technology and Management
Dwivedi, Harinath ; Babu Banarsi Das National Institute of Technology and Management
Kymonil, Koshy M.; Babu Banarsi Das National Institute ofTechnology and Management
Pareek, Ashutosh ; Dabur Research and Development Centre
Upadhyay, Satish Chandra; Dabur Research and Development Centre
Tripathi, Chandra Bhushan; Babasaheb Bhimrao Ambedkar University (A Central University)
Saraf, Shubhini A; Babasaheb Bhimrao Ambedkar University (A Central University)
 
Uncontrolled Index Term Anti-inflammatory, Bioavailability enhancement, Boswellia serrata extract, Self microemulsifying drug delivery system, 11-keto-β boswellic acid, 3 acetyl-11-keto-β-boswellic acid.
 
Summary, etc. <p><span>Boswellic acids (BAs) are isolated from oleo gum resin of </span><em>Boswellia serrata </em><span>Roxb. ex Colebr. and are reported to have anti-inflammatory, immunomodulatory and anti-tumor activity with better tolerance and lesser side effects compared to NSAIDs. Pharmacokinetic studies of BAs revealed its poor absorption through oral route due to poor solubility. The present study was aimed to develop and characterize a lipid based drug delivery system of <em>Boswellia serrata</em> extract (BSE) to enhance the solubility and in turn, the oral absorption of BAs. Suitable compositions for lipidic formulation were screened <em>via </em>solubility and compatibility studies. Pseudoternary phase diagrams were used to evaluate the microemulsion existence area. The self microemulsifying drug delivery system (SMEDDS) was characterized by solubility, clarity, drug precipitation, globule size, emulsification time and drug release profile. The optimal formulation of SMEDDS comprised of 37.5 % Tween-80, 12.5 % PEG-400 and 50 % oil (Caprylic/capric triglycerides). The dissolution study in hydrochloric acid buffer pH 1.2 showed significantly improved dissolution of BSE-SMEDDS (&gt;90 %) compared to Plain BSE (practically no release) in 120 minutes. BSE-<span lang="&quot;EN-GB&quot;">SMEDDS showed better anti-inflammatory activity than plain BSE in a <span lang="&quot;EN-GB&quot;">carrageenan-induced rat paw edema<span lang="&quot;EN-GB&quot;"> model. <span lang="&quot;EN-GB&quot;">The developed formulation was found to have better solubility and can be used as a possible alternative to traditional oral formulations of BSE with potential applications.</span></span></span></span></span></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-04-22 09:30:54
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/9875
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 1 (2016): March 2016
 
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