Record Details

Review on murine models available for dengue vaccine development

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement Review on murine models available for dengue vaccine development
 
Added Entry - Uncontrolled Name Bendran, Akash Parthi; Universiti Sains Malaysia
Murugaiyah, Vikneswaran ; University Sains Malaysia
Ramanathan, Surash ; Universiti Sains Malaysia
 
Uncontrolled Index Term Immunology, Pharamacology and Mouse models
Animal models, Antiviral drugs, Dengue virus, Immunopathogenesis, Pathogenesis, Vaccines.
 
Summary, etc. <p><span>Dengue is one of the most lethal and wide spread diseases with an estimated 5,00,000 cases being reported each year. Despite this, there are no targeted antivirals or vaccines approved for treatment. This could be attributed to the lack of appropriate animal models available to carry out dengue vaccine testing. A developed rodent model will be ideal for vaccine testing in laboratory. One major setback is that wild type mice are resistant to dengue virus replication. Interferon deficient mice are considered to be the most accurate model for vaccine testing as it recapitulates all the vital characteristics of severe dengue disease manifestation. Therefore, for development of dengue vaccine, interferon deficient mouse model will be a rigid model for testing and development of dengue-specific vaccines or antivirals.</span></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-11-28 13:23:53
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/13785
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 3 (2016): September 2016
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.