Review on murine models available for dengue vaccine development
Online Publishing @ NISCAIR
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Title Statement |
Review on murine models available for dengue vaccine development |
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Added Entry - Uncontrolled Name |
Bendran, Akash Parthi; Universiti Sains Malaysia Murugaiyah, Vikneswaran ; University Sains Malaysia Ramanathan, Surash ; Universiti Sains Malaysia |
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Uncontrolled Index Term |
Immunology, Pharamacology and Mouse models Animal models, Antiviral drugs, Dengue virus, Immunopathogenesis, Pathogenesis, Vaccines. |
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Summary, etc. |
<p><span>Dengue is one of the most lethal and wide spread diseases with an estimated 5,00,000 cases being reported each year. Despite this, there are no targeted antivirals or vaccines approved for treatment. This could be attributed to the lack of appropriate animal models available to carry out dengue vaccine testing. A developed rodent model will be ideal for vaccine testing in laboratory. One major setback is that wild type mice are resistant to dengue virus replication. Interferon deficient mice are considered to be the most accurate model for vaccine testing as it recapitulates all the vital characteristics of severe dengue disease manifestation. Therefore, for development of dengue vaccine, interferon deficient mouse model will be a rigid model for testing and development of dengue-specific vaccines or antivirals.</span></p> |
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Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2016-11-28 13:23:53 |
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Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJNPR/article/view/13785 |
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Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 3 (2016): September 2016 |
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Language Note |
en |
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Terms Governing Use and Reproduction Note |
Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific & Industrial Research, New Delhi. |
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