Record Details

<span>Hepatoprotective activity of </span><em>Luffa cylindrica </em><span>(L.) M. J. Roem</span><em>.</em><span> leaf extract in paracetamol intoxicated rats</span>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <span>Hepatoprotective activity of </span><em>Luffa cylindrica </em><span>(L.) M. J. Roem</span><em>.</em><span> leaf extract in paracetamol intoxicated rats</span>
 
Added Entry - Uncontrolled Name Sharma, Neeraj Kant
Priyanka
Jha, Keshari Kishore
Singh, Hemant Kumar
Srivastava, Anil Kumar
 
Uncontrolled Index Term Hepatoprotective, Luffa cylindrica, Methanolic extract, Paracetamol.
 
Summary, etc. <span>Methanolic extract of </span><em>Luffa cylindrica</em><span> (L.) M. J. Roem</span><em>. </em><span>leaves (MELC) was evaluated for its hepatoprotective potential against paracetamol intoxicated wistar rats. Administration of MELC and standard drug silymarin showed significant (</span><em>P </em><span>&lt;0.05) hepatoprotective protection in experimental animals. The study was conducted by estimating serum enzyme activities of serum glutamate oxaloacatate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT)), alkaline phosphatase (ALP) and  bilirubin and by estimation of some serum antioxidant enzymes. Elevated serum marker enzymes of SGOT, SGPT, ALP and serum bilirubin were significantly (</span><em>P </em><span>&lt;0.001) reduced to near normal level in MELC treated animals. Lipid peroxidation level was decreased significantly by MELC 250 mg/kg and 500 mg/kg doses treatment groups. In case of antioxidant enzymes SOD, GSH and catalase levels were increased significantly (</span><em>P </em><span>&lt;0.001) after treatment with MELC. The extract showed a dose-dependent reduction of paracetamol induced elevated serum levels of enzyme activities indicating the extract could preserve the normal functional status of the liver. Results of this study demonstrated that </span><em>L. cylindrica</em><span> has good hepatoprotective potential.</span>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-02-19 10:05:16
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJNPR/article/view/12454
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 5, ##issue.no## 2 (2014): June 2014
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.