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<p><span>Anti-stress and muscular endurance effects of natural specimens and laboratory cultured mycelia of </span><em>Ophiocordyceps sinensis</em><span> (Berk.) G.H. Sung, J.M. Sung on rats and mice</span></p>
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| Title Statement |
<p><span>Anti-stress and muscular endurance effects of natural specimens and laboratory cultured mycelia of </span><em>Ophiocordyceps sinensis</em><span> (Berk.) G.H. Sung, J.M. Sung on rats and mice</span></p> |
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Meena, Harsahay ; Scientist ‘C’ Defence Institute of Bio-Energy Research (DIBER), DRDO, Field Station, Pithoragarh-262501. (Uttarakhand) India. Singh, Kshetra Pal; Scientist ‘B’ Defence Institute of Bio-Energy Research (DIBER), DRDO, Field Station, Pithoragarh-262501. (Uttarakhand) India. Negi, Prem Singh; Scientist ‘E’, Defence Institute of Bio-Energy Research (DIBER), DRDO, Field Station, Pithoragarh-262501. (Uttarakhand) India Nasim, Mohammed ; Scientist ‘G’, Director, Defence Institute of Bio-Energy Research (DIBER), DRDO, Haldwani, Distt. Nainital (Uttarakhand) India. DRDO |
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Pharmacology, behavioral study Ophiocordyceps sinensis, Anti-stress, Muscular endurance, Rat and Mice, Caterpillar Mushroom, Medicinal Fungus |
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| Summary, etc. |
<p><em>Ophiocordyceps sinensis</em><span lang=""EN-GB""> (Berk.) G.H. Sung, J.M. Sung. is an entomogenous fungus, used as physical performance enhancer and herbal medicine for preventing or curing a number of human ailments. Owing to its high medicinal value and expensive market price, the present study was aimed to determine the anti-stress and muscular endurance effects of natural and laboratory cultured <em>O</em>. <em>sinensis </em>in animals. The natural specimens collected from 4000 – 5000 m altitude of Central Himalayan hills as well as the lab cultured mycelium were tested for anti-stress activity in rats and muscular endurance effect in mice with the help of Force Swim Test. Three doses (100, 300 and 500 mg/kg body wt.) of natural specimens and lab cultured <em>O. sinensis</em> were administered in test groups and Imipramine (15 mg/kg body wt.) in positive control group and 0.9 % NaCl solution in control group for 30 days.<br /> Natural specimens (100, 300 and 500 mg) and lab cultured (300 and 500 mg) of <em>O</em>. <em>sinensis</em> showed anti-stress and muscular endurance effects significantly (p<0.05) following oral administration. Natural specimens and lab cultured <em>O. sinensis</em> at doses of 300 and 500 mg/kg significantly (p<0.05) inhibited the increase in LDH, cholesterol and BUN and decrease in ALP level of immobilized stress rats. Thus, both natural and lab cultured <em>O</em>. <em>sinensis</em> have almost equal anti-stress and muscular endurance effect.</span></p> |
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| Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2016-02-19 08:35:30 |
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| Electronic Location and Access |
"application/pdf" http://op.niscair.res.in/index.php/IJNPR/article/view/3306 |
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Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 5, ##issue.no## 3 (2014): September 2014 |
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en |
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http://op.niscair.res.in/index.php/IJNPR/article/download/3306/6167 |
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Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific & Industrial Research, New Delhi. |
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