ICAR Research Data Repository for Knowledge Management
Anti-osteoporotic activity of ethanol extract of <em>Terminalia arjuna</em> (Roxb.) Wight & Arn. on ovariectomized rats
Online Publishing @ NISCAIR
View Archive Info| Field | Value | |
| Authentication Code |
dc |
|
| Title Statement |
Anti-osteoporotic activity of ethanol extract of <em>Terminalia arjuna</em> (Roxb.) Wight & Arn. on ovariectomized rats |
|
| Added Entry - Uncontrolled Name |
Trivedi, A Katti, H R; epartment of Orthopedics, S. Nijalingappa Medical College and Research Centre, Bagalkot-587101, Karnataka, India. Shalavadi, M H; Department of Pharmacology, Hanagal Shri Kumareshawr College of Pharmacy, BVVS campus, Bagalkot-587101, Karnataka, India. Ramkishan, A ; Drug controller (India), CDSCO, Subzonal Office, Airport, Ahmedabad- 380015, Gujarat, India. Chandrashekhar, V M; Department of Pharmacology, Hanagal Shri Kumareshawr College of Pharmacy, BVVS campus, Bagalkot-587101, Karnataka, India. VGST/P-8/CISE/2011-2/1151 from Vision Group on Science and Technology, Department of IT, BT & Science and Technology, Govt. of Karnataka, Bangalore, Karnataka |
|
| Uncontrolled Index Term |
isease and pest control measures, utilization of plants and animals in broader sense Terminalia arjuna, estrogen, postmenopausal osteoporosis, ash content, bone mineral density. |
|
| Summary, etc. |
<p><em></em><em>Terminalia arjuna </em>(Roxb.) Wight & Arn.,<em> </em>a widely growing plant in India, possesses different medicinal properties and its<em> </em>bark is well known for their bone remineralization properties. The objective of present study was to evaluate anti-osteoporotic activity of ethanol extract of <em>T. arjuna </em>(EET) on ovariectomized female Sprague Dawley model rats, divided into six groups. Sham operated control group received vehicle, standard group received estrogen (0.0563 mg/kg) and the remaining ovariectomized groups were orally administered with EET at 100, 300 and 500 mg/kg body weight, respectively for 42 days. The findings were assessed by uterine weight, bone loss determined by CT-scanning of femur, ash content, biomechanical, biochemical and histopathological parameters. Ethanol extract showed significant increase in uterine weight and femoral bone length, weight, density and significant increase of ash weight, ash percentage, ash calcium and hardness in lumbar vertebrae as compared to control group. EET treated groups also showed significant decrease level of creatinine, calcium and phosphorus (<em>p</em><0.01 to <em>p</em><0.001) as compared to control group. Histopathological studies further supported protective effect of the extract. These findings suggest a potential protective role of EET<em> </em>against estrogen deficient osteoporosis in ovariectomized rats.</p> |
|
| Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2015-12-14 15:51:40 |
|
| Electronic Location and Access |
"application/pdf" http://op.niscair.res.in/index.php/IJNPR/article/view/5268 |
|
| Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 6, ##issue.no## 2 (2015): June 2015 |
|
| Language Note |
en |
|
| Nonspecific Relationship Entry |
http://op.niscair.res.in/index.php/IJNPR/article/download/5268/12112 |
|
| Terms Governing Use and Reproduction Note |
Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific & Industrial Research, New Delhi. |
|