Record Details

<p><em>In silico</em><span> and </span><em>in vitro</em><span> anthelmintic activity of β-sitosterol isolated from rhizomes of </span><em>Hedychium spicatum</em><span> Buch.-Ham.</span></p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p><em>In silico</em><span> and </span><em>in vitro</em><span> anthelmintic activity of β-sitosterol isolated from rhizomes of </span><em>Hedychium spicatum</em><span> Buch.-Ham.</span></p>
 
Added Entry - Uncontrolled Name Sravani, T
Paarakh, Padmaa M; TheOxford College of Pharmacy
Shruthi, S D
The Oxford College of Pharmacy
 
Uncontrolled Index Term utilization of plants
Anthelmintic activity, β-Sitosterol, Docking, Hedychium spicatum, Zingiberaceae, Tubulin.
 
Summary, etc. <p class="Default"><em>Hedychium spicatum </em><span>Buch.-Ham. (Family-Zingiberaceae), commonly known as spiked ginger lily, is found in the entire Himalayan region. The rhizomes are reported to be used as tranquilizer, hypotensive, antispasmodic, CNS depressant, analgesic, anti-inflammatory, antimicrobial, antioxidant, antifungal, pediculicidal, cytotoxic and anthelmintics. The present study is an attempt to explore the anthelmintic activity of β-sitosterol isolated from the rhizomes of </span><em>H. spicatum </em><span>by molecular docking with tubulin and <em>in vitro</em> activity<em> </em>against adult Indian earthworms, <em>Pheretima posthuma</em>. β-sitosterol binds very efficiently within the active pocket of tubulin which is better when compared to orientation of standard drug, Piperazine citrate. These results were also confirmed with <em>in vitro</em> study. The time taken for each worm for paralysis and death were determined. The time taken for paralysis and death with β-sitosterol at 40 mg/mL was comparable to standard Piperazine citrate.</span></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-02-19 08:35:30
 
Electronic Location and Access "application/pdf"
http://op.niscair.res.in/index.php/IJNPR/article/view/3752
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 5, ##issue.no## 3 (2014): September 2014
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed underCreative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2012. The Council of Scientific &amp; Industrial Research, New Delhi.