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<p><span>Protective effect of </span><em>Psidium guajava </em><span>L. leaves ethanolic extract on doxorubicin-induced nephrotoxicity in rats</span></p>

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Title Statement <p><span>Protective effect of </span><em>Psidium guajava </em><span>L. leaves ethanolic extract on doxorubicin-induced nephrotoxicity in rats</span></p>
 
Added Entry - Uncontrolled Name Mohan, Mahalaxmi ; Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda, Narapally, R.R. District, Hyderabad-500 094
Shashank, B
Priya, A Vishnu
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Uncontrolled Index Term pharmacology
Antioxidant, Doxorubicin, Nephrotoxicity, Psidium guajava
 
Summary, etc. <p><span>The objective of the present study was to investigate the protective effect of ethanolic extract of </span><em>Psidium guajava</em><span> L. leaves against doxorubicin-induced nephrotoxicity in rats. Animals treated with doxorubicin (8mg/kg, i.p) once daily for 2 days significantly (P&lt;0.05) increased Serum Urea, BUN, creatinine, total protein, LPO and significantly (</span><em>P</em><span>&lt;0.05) decreased CAT, SOD, GSH levels as compared to vehicle treated rats. Treatment with </span><em>P. guajava</em><span> (100 &amp; 300 mg/kg, p.o) showed significant (</span><em>P</em><span>&lt;0.05) decrease in Serum Urea, BUN, creatinine, total protein, LPO and significant (</span><em>P</em><span>&lt;0.05) increase in CAT, SOD, GSH levels as compared to doxorubicin treated group. Histopathological examinations of kidney tissue showed that doxorubicin changed the renal architecture significantly which was less evident in </span><em>P. guajava</em><span> (100 mg/kg &amp; 300 mg/kg) pre-treated rats. Results suggest that </span><em>P. guajava</em><span> extract has the potential to ameliorate doxorubicin induced nephrotoxicity and might serve as a novel combination agent with doxorubicin to limit renal damage.</span></p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-02-19 10:05:16
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/2463
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 5, ##issue.no## 2 (2014): June 2014
 
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