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A protective effect of <em>Symphorema polyandrum</em> Wight seeds against <em>Naja naja</em> venom- Pharmacological evaluation

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Title Statement A protective effect of <em>Symphorema polyandrum</em> Wight seeds against <em>Naja naja</em> venom- Pharmacological evaluation
 
Added Entry - Uncontrolled Name Lakhmale, Sarang ; Ph. D. scholar, Dept of Dravyaguna Institute for Post Graduate Teaching & Research in Ayurveda Gujrat Ayurved University, Jamnagar, 361008, Gujrat, India
Acharya, R N; Institute for PG Teaching and research in Ayurveda
Chavan, Sulakshan S; Gujarat Ayurved Univesity
K, Ashok B; Drug Discovery Group, R & D, The Himalaya Drug Company, Makali, Bangalore
B, Ravishankar ; Director, SDM centre for research in Ayurveda and allied sciences Udupi
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Uncontrolled Index Term Ayurvedic pharmacology
Antivenom, Naja naja, Symphorema polyandrum Wight
 
Summary, etc. <em>Symphorema polyandrum </em>Wight (Family Verbenaceae), an ethnomedicinal plant, is reported for its use in the management of snake bite by the tribal people of Odisha. In this study, the efficacy of <em>S. polyandrum</em> was evaluated for its antivenom activity. Seed powder 360 mg/kg was given to envenomed albino rats with sub-lethal dose of <em>Naja naja</em> venom (0.5 mg/kg), in normal saline by intraperitonial injection. Biochemical parameters like serum cholesterol, serum triglyceride, HDL cholesterol, serum total protein, albumin, globulin, alkaline phosphatase, blood sugar, SGPT and in haematological investigation only the total count was found significantly reversing the effect of venom between venom control and test drug group. The study also showed that the envenomation of rats led to increase in lipid peroxidation in all the three tissues. Administration of the test drug to venomised rat significantly decreased the lipid peroxidation in liver and heart. Further, it also enhanced the anti-oxidant activity through enzyme catalase in liver and heart.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-04-12 09:57:06
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/1267
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 4 (2016): December 2016
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/1267/1908
 
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