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Evaluation of immunomodulatory activity of <em>Balachaturbhadra Churna</em>- An <em>Ayurvedic</em> formulation

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Title Statement Evaluation of immunomodulatory activity of <em>Balachaturbhadra Churna</em>- An <em>Ayurvedic</em> formulation
 
Added Entry - Uncontrolled Name Joshi, Abhishek J; Seat of Ayurveda, Program Studi Kesehatan Ayurweda
Aparna, K ; Department of Basic principles, Institute for post graduate teaching and research in Ayurveda
Rajagopala, Shrikrishna ; Department of Kaumarabhritya, Institute for post graduate teaching and research in Ayurveda
Patel, Kalpana Shantibhai; Department of Kaumarabhritya, Institute for post graduate teaching and research in Ayurveda
Nariya, Mukeshkumar ; Pharmacology Laboratory, Institute for post graduate teaching and research in Ayurveda
K, Ashok B; Research & development Himalaya drug company
IPGT&RA, Jamnagar
 
Uncontrolled Index Term Ayurveda, Pharmacology
Balachaturbhadra Churna, Cell-mediated immunity, Cytoprotective activity, Hemagglutination titer, Humoral immunity.
 
Summary, etc. <em>Balachaturbhadra churna</em> (BCBC) is an extensively used poly-herbal formulation of <em>Ayurveda </em>for pediatrics disorders.It is indicated for respiratory disorders, fever, diarrhoea, and vomiting. It is practiced as a potent immune enhancer in children. The present study was undertaken to evaluate immunomodulatory activity of BCBC to validate the classical claims of therapeutic efficacy made on it. The cell-mediated immune response was evaluated against triple antigen induced immunological paw edema in pre-sensitized rats. The humoral immune response against cyclophosphamide induced immunosuppression in sheep red blood cells (SRBC) pre-sensitized rats was evaluated by hemagglutination titer, ponderal changes, and histopathological studies. BCBC produced significant increase (P&lt;0.05) in immunological paw edema in triple antigen pre-sensitized rats and significant increase (P&lt;0.05) in hemagglutination titer value in humoral immune response compared to control and vehicle control groups. The drug had significant effect in reversal of cyclophosphamide induced immune suppression in thymus, spleen, and lymph nodes. The results indicate a significant effect of the BCBC on cell-mediated immune response and humoral immune response. The reversal of cyclophosphamide induced immune suppression of organs indicates cytoprotective activity of BCBC in rats.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-04-12 09:57:06
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/11467
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 4 (2016): December 2016
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/11467/32561
http://op.niscair.res.in/index.php/IJNPR/article/download/11467/32562
http://op.niscair.res.in/index.php/IJNPR/article/download/11467/32563
 
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