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Anti obesity mechanism of <em>Curcuma longa</em> L.: An Over view

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Title Statement Anti obesity mechanism of <em>Curcuma longa</em> L.: An Over view
 
Added Entry - Uncontrolled Name Yadav, Kapil Deo; Banaras Hindu University
Chaudhary, Anand K; Professor Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005
 
Uncontrolled Index Term Curcuma longa L., Inflammatory mediators, Obesity, Reactive oxygen species.
 
Summary, etc. <p><span>Chronic low grade inflammation is one important reason for the development of obesity and the inflammation is initiated by excess nutrient from metabolic cell and is characterized by increasing TNFα, interlukins, cytokinines, etc. Besides this, genetic, social, behavioural and environmental factors alone or interaction with each other influences diet, physical activity by affecting </span><span lang="&quot;EN-US&quot;">complex hypothalamic neuro-circuitry. These increase leptin level, inflammatory mediators and reactive oxygen species (ROS), which positively correlate with obesity.<em> Curcuma longa</em> L., commonly known as <em>Haridra</em> have been used for treatment of obesity and diabetes since ancient time in <em>Ayurveda</em><span>, the Indian traditional system of medicine. From current research, it has been observed that <em>C. longa</em> inhibit<span lang="&quot;EN-US&quot;"> secretion of leptin, pro-inflammatory mediators and over production of ROS, whereas it increases secretion of insulin, <span lang="&quot;EN-GB&quot;">adiponectin<span lang="&quot;EN-US&quot;"> in plasma. Increased serum <span lang="&quot;EN-GB&quot;">adiponectin<span lang="&quot;EN-US&quot;"> insulin and decreased production of ROS negatively correlate with obesity. In addition to these, <em>C. longa </em>inhibit early growth response (Egr-1) gene, which is related to development of obesity. It is clear that by affecting leptin,<span> adiponectin, inflammatory mediators, ROS, regulating nutritional environment and Egr-1 gene, lipogenic gene and ob gene, <em>C. longa</em> may be affirmative for management of obesity.</span></span></span></span></span></span></span></span></p><strong> </strong>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2016-06-29 15:07:39
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/7773
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 7, ##issue.no## 2 (2016): June 2016
 
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