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<em>In vitro</em> antioxidant and <em>in vivo</em> prophylactic effects of heptyl 3-(2-formylphenyl) propanoate isolated from <em>Delonix elata </em>L. against hepatoxicity in CCl<sub>4</sub> intoxicated rats

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Title Statement <em>In vitro</em> antioxidant and <em>in vivo</em> prophylactic effects of heptyl 3-(2-formylphenyl) propanoate isolated from <em>Delonix elata </em>L. against hepatoxicity in CCl<sub>4</sub> intoxicated rats
 
Added Entry - Uncontrolled Name Krishnappa, Pradeepa ; Kuvempu University
Venkatarangaiah, Krishna ; Kuvempu University
Venkatesh; Kuvempu University
Shimoga Rajanna, Santosh Kumar ; Kuvempu University
Department of Biotechnology, New Delhi
 
Uncontrolled Index Term phrmacognosy; phytochemistry
Antioxidant activity, Delonix elata, Hepatoprotective activity, Heptyl 3-(2-formylphenyl) propanoate
 
Summary, etc. <em>Delonix elata</em> L. (Family Caesalpiniaceae) has been used in the folklore medicines in Karnataka, India to cure liver and rheumatic problems. Bioassay guided fractionation of the chloroform leaf extract of <em>D. elata </em> has resulted in the isolation of heptyl 3-(2-formylphenyl) propanoate (HFP). The prophylactic activity of leaf chloroform extract (DLC) and the isolated constituent were evaluated against CCl<sub>4</sub>-induced hepatotoxicity in rats. The treatment with DLC and HFP with concomitant CCl<sub>4</sub> intraperitoneal injection significantly reduced the elevated plasma levels of AST, ALT, ALP, triglycerides, and cholesterol compared with the CCl<sub>4</sub> injected group. DLC and HFP showed significant prophylactic effect on activities of SOD, CAT, GPx, GST, and also significantly inhibited the elevated levels of MDA in liver homogenates. Results obtained in biochemical assays were well supported by histological observations. The results revealed that the hepatoprotective activity of DLC and HFP is significant and on par with the standard drug silymarin. To clarify the influence of the DLC and HFP on the protection of oxidative-hepatic damage, <em>in vitro</em> antioxidant properties were examined. Free radical scavenging activity was exhibited by both, the extract and the constituent. The results suggest that the DLC and HFP could protect the hepatocytes from CCl<sub>4</sub>-induced liver damage perhaps, by their anti-oxidative effect on hepatocytes.
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2017-06-02 15:25:38
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/10073
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 8, ##issue.no## 1 (2017): March 2017
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28204
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28206
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28207
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28208
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28209
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28210
http://op.niscair.res.in/index.php/IJNPR/article/download/10073/28211
 
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